Use of Collagen Sheets Simulating Various Skin Types and Age Groups to Evaluate Human Skin Damage Caused by Ultraviolet Light
نویسندگان
چکیده
منابع مشابه
Ultraviolet light induced alteration to the skin.
Solar light is the primary source of UV radiation for all living systems. UV photons can mediate damage through two different mechanisms, either by direct absorption of UV via cellular chromophores, resulting in excited states formation and subsequent chemical reaction, or by phosensitization mechanisms, where the UV light is absorbed by endogenous (or exogenous) sensitizers that are excited an...
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Ultraviolet-B (UVB) (290-320 nm) radiation-induced cyclobutane pyrimidine dimers within the DNA of epidermal cells are detrimental to human health by causing mutations and immunosuppressive effects that presumably contribute to photocarcinogenesis. Conventional photoprotection by sunscreens is exclusively prophylactic in nature and of no value once DNA damage has occurred. In this paper, we hav...
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The incidence of melanoma and nonmelanoma skin cancers is increasing worldwide. Ultraviolet light exposure is the most important risk factor for cutaneous melanoma and nonmelanoma skin cancers. Nonmelanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma. Constitutive skin color and genetic factors, as well as immunological factors, play a role in the development of skin ca...
متن کاملHuman skin collagen from different age groups before and after collagenase digestion; an electron microscopic study.
That some alteration in collagen occurs with age has been indicated by various workers. Young rat tendon (Neuberger and others, 1951) shows a greater radioactive glycine turnover than that of adult animals. Similar findings were reported in the skin of rats (Neuberger and Slack, 1953) and rabbits (Harkness and Neuberger, 1952). Under the electron microscope the collagen fibres in newborn rat sk...
متن کاملUltraviolet B-induced DNA damage in human skin and its modulation by a sunscreen.
The UVB component of solar radiation is a risk factor for skin cancer, the most common cancer in the Western world. Yet little is known about the induction of DNA damage in human skin by UVB and its modulation by sunscreens. Here, we apply a novel postlabeling high-performance liquid chromatography technique to quantify UVB-induced photoproducts in skin biopsies with and without sunscreen. The ...
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ژورنال
عنوان ژورنال: Journal of the Society of Materials Science, Japan
سال: 2018
ISSN: 0514-5163,1880-7488
DOI: 10.2472/jsms.67.746